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Blocking APE1 enzyme could provide new way to kill cancer cells

October 30, 2017

Professor Steve Jackson, a DNA damage repair expert, said: "Destroying cancer cells by knocking out two repair mechanisms simultaneously is emerging as an important way to treat the disease. We've already made strides in developing treatments that do this, and this new research builds on that work.

"This promising new target may lead to even more specific drugs capable of delivering a knock-out double blow to cancer cells, leaving healthy cells unharmed - so potentially causing fewer side effects.

"It also brings fresh hope for the development of new drugs which can be prescribed when patients become resistant to conventional treatments. We'll look forward to further development of potential new drugs to block this very specific target with great interest."

Baroness Delyth Morgan, Chief Executive of Breast Cancer Campaign, which part-funded the research, said: "With up to ten per cent of all breast cancers thought to result from faulty BRCA1 and/or 2 genes, new treatments for these patients could possibly help up to 4,800 of the women diagnosed with the disease in the UK each year. Currently there are limited options available to them and this potential new treatment, although at an early stage could provide a real lifeline and a better chance of survival, which can only be good news."

Source: Cancer Research UK