British scientists find seven new gene variants linked to prostate cancer

June 22, 2017

However, the variant found in this study is in a different region of the gene to those linked to other cancers, suggesting that this particular variant is unique to prostate cancer. Using data on the health of the men in the study the researchers were also able to link this SNP to an increase in PSA level.

Another new SNP found on chromosome 5 is in a gene called FGF10 that is often switched on in breast cancers and there is some evidence that suggests it plays a role in the growth of normal prostate cells.

One of the SNPs found in this study, on chromosome six in the gene CCHCR1, has also been linked to the inflammatory condition psoriasis and this gene is also switched on in skin cancer.

Prostate cancer is the most common cancer in men in the UK. A quarter of all new cases of cancer diagnosed in men are prostate cancers. In 2008, more than 37,000 men in the UK were diagnosed with the disease. Each year around 10,000 men in the UK die from prostate cancer.

Dr Julie Sharp, senior science information manager at Cancer Research UK, said: ???This type of research is vital to understanding more about prostate cancer and will help researchers to find new ways to prevent the disease and develop more targeted treatments. Genome wide association studies are a powerful tool to find common factors that increase the risk of developing cancer and this is an area that Cancer Research UK has been committed to for a number of years. This work has been made possible thanks to the generosity of the public. We are now entering an exciting period when this research will begin to have a real benefit for cancer patients.???

Source: wwwncerresearchuk