Infinity commences two IPI-145 Phase 1 clinical trials for hematologic malignancies

October 15, 2017

The first Phase 1 trial of IPI-145 is a double-blind, randomized, placebo-controlled study designed to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of single and multiple escalating doses of IPI-145 in healthy adult subjects.

The second Phase 1 trial is an open-label, dose-escalation study designed to evaluate the safety, pharmacokinetics and clinical activity of IPI-145 in patients with advanced hematologic malignancies. Following the determination of the maximum tolerated dose in the dose escalation phase, an expansion phase will follow in patients with selected hematologic malignancies.

"The initiation of these Phase 1 trials of IPI-145 marks the achievement of a key development objective for Infinity this year," stated Adelene Q. Perkins, president and chief executive officer at Infinity. "We have started seven clinical studies in 2011, an accomplishment that we believe underscores the productivity of our R&D organization, highlights our commitment to developing therapies for underserved diseases and increases our potential for long-term growth and success."

Source Infinity Pharmaceuticals, Inc.