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Research may help explain why live attenuated influenza vaccine elicits protection

July 16, 2017

The study goes on to show that the LAIV vaccine also induces a robust immune response in healthy adult volunteers. These translational experiments were carried out in collaboration with the Respiratory Diseases Research Department at the Naval Health Research Center (NHRC) in San Diego, CA and were the result of a joint Trudeau/Department of Defense contract.

Subjects were recruited by NHRC and were administered the commercially available FluMist vaccine. At specific time points following vaccination, the immune response to the vaccine was examined. Following LAIV vaccination, chemokines and cytokines involved in virus-specific lymphocyte recruitment were produced. This is indicative of a protective immune response and would lead to the early recruitment of immune cells to the lung should influenza infection occur. Importantly, early recruitment of immune cells to the lung is highly desirable since this then leads to accelerated viral clearance and reduced levels of inflammation.

Source: Trudeau Institute