Research: Nucleolar disruption could destroy cancer cells

November 03, 2017

Until now, nucleoli were just thought to be the places where ribosomes - 'protein factories' - are made. This research shows nucleoli have additional cell control functions and provide the link between the detection of cell stress and the cells' response.

Professor Sir David Lane, co-discoverer of p53, said: "We discovered p53 - the first natural 'tumour suppressor protein,' which protects cells from turning cancerous - more than 30 years ago.

"But decades later, our team and other scientists are still making incredible discoveries about the behaviour of p53 - and the many ways it regulates cells.

"Today it is at the heart of new techniques being developed to treat cancer. And this latest finding, that a simple part of the cell could potentially be targeted to increase the levels of p53, is exciting news and has the potential to influence greatly the development of future approaches to destroying cancer cells."

Source: Cancer Research UK