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A total of 74 women with PCOS took part in the study, which also shows that the aberrations in adipose tissue in PCOS could play a key role in increasing these women's risk of developing type 2 diabetes. The factors linked most strongly with insulin resistance were the size of the fat cells, the quantity of adiponectin in the blood and waist size. However, testosterone levels did not play a significant role in this analysis.
"We don't entirely understand the mechanism behind the large fat cells' unfavourable effects, but the results show that it is particularly important for the health of women with PCOS that they don't put on weight," says Manner??s-Holm.
POLYCYSTIC OVARY SYNDROME (PCOS)
PCOS is the most common hormonal disorder in women of fertile age. Characterised by insulin resistance and high levels of testosterone, PCOS affects 5-10% of fertile women.
The most common symptoms are irregular or disrupted menstruation, problem hair growth, acne and excess weight. In the long term women with PCOS are at greater risk of developing type 2 diabetes, and probably cardiovascular disease too. Extensive research is under way to increase our knowledge of the underlying factors.
Docent Malin L?¶nn at the Sahlgrenska Academy supervised the study of adipose tissue in PCOS, which was part of an extensive investigation into these women's physical and mental health led by docent Elisabet Stener-Victorin at the Sahlgrenska Academy.
Source: University of Gothenburg