Heart failure risk rises in people with diastolic dysfunction: Study

June 12, 2017

???That diastolic dysfunction worsened even in healthy persons supports the concept that aging may be accompanied by progressive deterioration in diastolic function. This age-related progression of diastolic dysfunction in the population contributes to the pathophysiologic substrate from which overt heart failure emerges,??? said Dr. Kane.

???Specifically, our findings are consistent with the hypothesis that a combination of cardiovascular aging and superimposed cardiovascular disease accelerates the deterioration in diastolic function, setting the stage for symptomatic heart failure with preserved LVEF in elderly persons,??? researchers noted. It follows that preventing such superimposed events by addressing risk factors, particularly hypertension, ???might be fundamental to reducing heart failure with preserved LVEF,??? they added. The study findings may not be generalizable to nonwhite racial or ethnic populations, since the cohort was predominantly white.

This study was supported by the National Heart, Lung, and Blood Institute, the National Center for Research Resources, the Mayo Foundation, the National Institutes of Health, the Rochester Epidemiology Project, and the National Institute on Aging. No financial conflicts of interest were reported.