Individual genes and networks that play an important role in inflammation, atherosclerosis identified

March 18, 2017

HemoShear's unique, proprietary laboratory technology imparts human blood flow forces on blood vessel cells to simulate their biological function. In HemoShear's recent gene profiling study, the company's scientists conducted experiments with freshly harvested human cells to replicate healthy regions of the human artery system as well regions that are susceptible to disease. The purpose of the experiments was to develop a baseline understanding of human artery biology and to gain insight into how arterial inflammation and early atherosclerosis develop in humans. Atherosclerosis is a blood vessel inflammatory disease characterized by build-up of plaque in the arteries, which limits blood flow and can lead to heart attack and stroke.

"We are already using the data to confirm the roles of certain target genes in cardiovascular disease for our pharmaceutical customers," said Brian Wamhoff, Ph.D., HemoShear Co-founder and Vice President of R&D. "As we create new models of diseases with our technology, the baseline data that we generated in this study will help us determine what genes increase the risk of atherosclerosis in diseases such as diabetes and hypertension, and will accelerate discovery of new drug treatments."